ctcRbase

Entry Detail

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General Information

Database ID: SKCM06446 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LOXL2 Full Name: lysyl oxidase like 2 Category: mRNA Synonyms: LOR|LOR2|WS9-14 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 23297189 End Site(bp): 23425328 Gene Summary: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000134013 HGNC ID: HGNC:6666 Entrez Gene: 4017

Expression Profile of LOXL2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-1297 YES NO YES hsa-miR-149-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-369-3p YES NO NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-425-5p YES YES YES Display: