ctcRbase

Entry Detail

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General Information

Database ID: SKCM06503 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ZCCHC8 Full Name: zinc finger CCHC-type containing 8 Category: mRNA Synonyms: - Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 122471600 End Site(bp): 122501073 Gene Summary: This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017] External Links: Ensembl ID: ENSG00000033030 HGNC ID: HGNC:25265 Entrez Gene: 55596

Expression Profile of ZCCHC8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-93-5p YES YES NO Display: