ctcRbase

Entry Detail

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General Information

Database ID: SKCM06535 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FAM111A Full Name: family with sequence similarity 111 member A Category: mRNA Synonyms: GCLEB|KCS2 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 59142748 End Site(bp): 59155039 Gene Summary: The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] External Links: Ensembl ID: ENSG00000166801 HGNC ID: HGNC:24725 Entrez Gene: 63901

Expression Profile of FAM111A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-543 YES YES NO Display: