ctcRbase

Entry Detail

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General Information

Database ID: SKCM06601 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CCNF Full Name: cyclin F Category: mRNA Synonyms: FBX1|FBXO1 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 2429394 End Site(bp): 2458854 Gene Summary: This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000162063 HGNC ID: HGNC:1591 Entrez Gene: 899

Expression Profile of CCNF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-15a-5p YES NO NO hsa-miR-15b-5p YES NO NO hsa-miR-16-5p YES NO NO hsa-miR-186-5p YES NO YES hsa-miR-195-5p YES NO NO hsa-miR-216b-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-335-5p YES YES YES hsa-miR-424-5p YES NO NO hsa-miR-497-5p YES NO NO hsa-miR-503-5p YES NO NO hsa-miR-875-5p YES YES NO hsa-miR-98-5p YES YES YES Display: