ctcRbase

Entry Detail

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General Information

Database ID: SKCM06623 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CREBBP Full Name: CREB binding protein Category: mRNA Synonyms: CBP|KAT3A|RSTS|RSTS1 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 3725054 End Site(bp): 3880726 Gene Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] External Links: Ensembl ID: ENSG00000005339 HGNC ID: HGNC:2348 Entrez Gene: 1387

Expression Profile of CREBBP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES NO YES hsa-miR-147a YES NO NO hsa-miR-153-3p YES YES YES hsa-miR-186-5p YES YES YES hsa-miR-191-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-300 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-33a-5p YES NO YES hsa-miR-33b-5p YES NO YES hsa-miR-361-5p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES Display: