ctcRbase

Entry Detail

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General Information

Database ID: SKCM06635 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CAD Full Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Category: mRNA Synonyms: CDG1Z|EIEE50|GATD4 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 27217390 End Site(bp): 27243943 Gene Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] External Links: Ensembl ID: ENSG00000084774 HGNC ID: HGNC:1424 Entrez Gene: 790

Expression Profile of CAD Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-224-5p YES YES NO hsa-miR-455-3p YES NO YES Display: