ctcRbase

Entry Detail

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General Information

Database ID: SKCM06641 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SSRP1 Full Name: structure specific recognition protein 1 Category: mRNA Synonyms: FACT|FACT80|T160 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 57325985 End Site(bp): 57335877 Gene Summary: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000149136 HGNC ID: HGNC:11327 Entrez Gene: 6749

Expression Profile of SSRP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-217 YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-28-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-708-5p YES YES YES hsa-miR-874-3p YES YES NO Display: