ctcRbase

Entry Detail

---



General Information

Database ID: SKCM06690 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TFE3 Full Name: transcription factor binding to IGHM enhancer 3 Category: mRNA Synonyms: RCCP2|RCCX1|TFEA|bHLHe33 Chromosome: chrX Strand: - Coordinate: Start Site(bp): 49028726 End Site(bp): 49043486 Gene Summary: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] External Links: Ensembl ID: ENSG00000068323 HGNC ID: HGNC:11752 Entrez Gene: 7030

Expression Profile of TFE3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-491-5p YES YES NO Display: