ctcRbase

Entry Detail

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General Information

Database ID: SKCM06713 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PDK1 Full Name: pyruvate dehydrogenase kinase 1 Category: mRNA Synonyms: - Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 172555373 End Site(bp): 172608669 Gene Summary: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] External Links: Ensembl ID: ENSG00000152256 HGNC ID: HGNC:8809 Entrez Gene: 5163

Expression Profile of PDK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-137 YES YES NO hsa-miR-138-5p YES YES YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-421 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-96-5p YES YES YES Display: