ctcRbase

Entry Detail

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General Information

Database ID: SKCM06940 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LIMK1 Full Name: LIM domain kinase 1 Category: mRNA Synonyms: LIMK|LIMK-1 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 74082933 End Site(bp): 74122525 Gene Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000106683 HGNC ID: HGNC:6613 Entrez Gene: 3984

Expression Profile of LIMK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES NO YES hsa-miR-138-5p YES YES YES hsa-miR-143-3p YES YES YES hsa-miR-147a YES NO NO hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES YES hsa-miR-429 YES NO YES hsa-miR-491-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-541-3p YES NO NO hsa-miR-654-5p YES NO NO hsa-miR-655-3p YES NO YES hsa-miR-93-5p YES YES YES Display: