ctcRbase

Entry Detail

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General Information

Database ID: SKCM06967 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TDP1 Full Name: tyrosyl-DNA phosphodiesterase 1 Category: mRNA Synonyms: - Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 89954939 End Site(bp): 90044768 Gene Summary: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] External Links: Ensembl ID: ENSG00000042088 HGNC ID: HGNC:18884 Entrez Gene: 55775

Expression Profile of TDP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-128-3p NO YES YES hsa-miR-1-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-27a-3p NO YES NO hsa-miR-27b-3p NO YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-613 YES YES NO hsa-miR-93-5p YES YES NO Display: