ctcRbase

Entry Detail

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General Information

Database ID: SKCM06999 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CHM Full Name: CHM, Rab escort protein 1 Category: mRNA Synonyms: DXS540|GGTA|HSD-32|REP-1|TCD Chromosome: chrX Strand: - Coordinate: Start Site(bp): 85861180 End Site(bp): 86047562 Gene Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016] External Links: Ensembl ID: ENSG00000188419 HGNC ID: HGNC:1940 Entrez Gene: 1121

Expression Profile of CHM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-137 YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-613 YES YES NO hsa-miR-96-5p YES YES NO Display: