ctcRbase

Entry Detail

---



General Information

Database ID: SKCM07030 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FGFR1 Full Name: fibroblast growth factor receptor 1 Category: mRNA Synonyms: BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 38411138 End Site(bp): 38468834 Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000077782 HGNC ID: HGNC:3688 Entrez Gene: 2260

Expression Profile of FGFR1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-107 YES NO NO hsa-miR-1224-5p YES NO YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-192-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-296-5p YES NO YES hsa-miR-326 YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-330-5p YES NO YES hsa-miR-376a-3p YES YES YES hsa-miR-376b-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES NO NO hsa-miR-543 YES YES NO hsa-miR-551a YES YES NO hsa-miR-551b-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-665 YES NO YES Display: