ctcRbase

Entry Detail

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General Information

Database ID: SKCM07075 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TK2 Full Name: thymidine kinase 2, mitochondrial Category: mRNA Synonyms: MTDPS2|MTTK|PEOB3|SCA31 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 66508003 End Site(bp): 66552544 Gene Summary: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012] External Links: Ensembl ID: ENSG00000166548 HGNC ID: HGNC:11831 Entrez Gene: 7084

Expression Profile of TK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-613 YES YES NO Display: