ctcRbase

Entry Detail

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General Information

Database ID: SKCM07124 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CBFA2T2 Full Name: CBFA2/RUNX1 translocation partner 2 Category: mRNA Synonyms: EHT|MTGR1|ZMYND3|p85 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 33490075 End Site(bp): 33650036 Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000078699 HGNC ID: HGNC:1536 Entrez Gene: 9139

Expression Profile of CBFA2T2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-1197 YES NO YES hsa-miR-132-3p YES NO YES hsa-miR-139-5p YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-147a YES NO NO hsa-miR-155-5p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-212-3p YES NO YES hsa-miR-214-3p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-28-5p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-361-5p YES NO YES hsa-miR-495-3p YES YES YES hsa-miR-501-3p YES NO YES hsa-miR-502-3p YES NO YES hsa-miR-665 YES NO YES hsa-miR-708-5p YES YES NO Display: