ctcRbase

Entry Detail

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General Information

Database ID: SKCM07288 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PRDM16 Full Name: PR/SET domain 16 Category: mRNA Synonyms: CMD1LL|KMT8F|LVNC8|MEL1|PFM13 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 3069168 End Site(bp): 3438621 Gene Summary: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000142611 HGNC ID: HGNC:14000 Entrez Gene: 63976

Expression Profile of PRDM16 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-139-5p YES NO YES hsa-miR-141-3p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-205-5p YES NO YES hsa-miR-219a-5p YES YES YES hsa-miR-532-3p YES NO YES hsa-miR-543 YES NO YES hsa-miR-96-5p YES YES YES Display: