ctcRbase

Entry Detail

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General Information

Database ID: SKCM07301 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GLRX Full Name: glutaredoxin Category: mRNA Synonyms: GRX|GRX1 Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 95751319 End Site(bp): 95823005 Gene Summary: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000173221 HGNC ID: HGNC:4330 Entrez Gene: 2745

Expression Profile of GLRX Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-28-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-98-5p YES YES YES Display: