ctcRbase

Entry Detail

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General Information

Database ID: SKCM07337 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MADD Full Name: MAP kinase activating death domain Category: mRNA Synonyms: DENN|IG20|RAB3GEP Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 47269161 End Site(bp): 47330031 Gene Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000110514 HGNC ID: HGNC:6766 Entrez Gene: 8567

Expression Profile of MADD Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1197 YES NO YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-497-5p YES YES NO Display: