ctcRbase

Entry Detail

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General Information

Database ID: SKCM07365 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MAP2K1 Full Name: mitogen-activated protein kinase kinase 1 Category: mRNA Synonyms: CFC3|MAPKK1|MEK1|MKK1|PRKMK1 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 66386817 End Site(bp): 66492312 Gene Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000169032 HGNC ID: HGNC:6840 Entrez Gene: 5604

Expression Profile of MAP2K1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-149-5p YES NO YES hsa-miR-152-3p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-369-3p YES NO NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-411-5p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-758-3p YES YES YES hsa-miR-760 YES NO YES hsa-miR-873-5p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-96-5p YES YES YES Display: