| ncRNA Symbol: | PKN1 |
| Full Name: | protein kinase N1 |
| Category: | mRNA |
| Synonyms: | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 |
| Chromosome: | chr19 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 14433053 | End Site(bp): | 14471867 |
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| Gene Summary: | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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