ctcRbase

Entry Detail

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General Information

Database ID: SKCM07501 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CD276 Full Name: CD276 molecule Category: mRNA Synonyms: 4Ig-B7-H3|B7-H3|B7H3|B7RP-2 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 73683966 End Site(bp): 73714518 Gene Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] External Links: Ensembl ID: ENSG00000103855 HGNC ID: HGNC:19137 Entrez Gene: 80381

Expression Profile of CD276 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES NO YES hsa-miR-128-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-214-3p YES YES NO hsa-miR-223-3p YES NO NO hsa-miR-28-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-324-3p YES NO NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-338-3p YES NO YES hsa-miR-339-5p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-506-3p YES NO YES hsa-miR-599 YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-9-5p YES YES NO Display: