ctcRbase

Entry Detail

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General Information

Database ID: SKCM07513 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LEPR Full Name: leptin receptor Category: mRNA Synonyms: CD295|LEP-R|LEPRD|OB-R|OBR Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 65420652 End Site(bp): 65641559 Gene Summary: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] External Links: Ensembl ID: ENSG00000116678 HGNC ID: HGNC:6554 Entrez Gene: 3953

Expression Profile of LEPR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-300 YES NO NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES NO NO hsa-miR-384 YES YES NO hsa-miR-429 YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-96-5p YES YES NO Display: