ctcRbase

Entry Detail

---



General Information

Database ID: SKCM07532 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PPM1F Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1F Category: mRNA Synonyms: CAMKP|CaMKPase|FEM-2|POPX2|hFEM-2 Chromosome: chr22 Strand: - Coordinate: Start Site(bp): 21919420 End Site(bp): 21952837 Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000100034 HGNC ID: HGNC:19388 Entrez Gene: 9647

Expression Profile of PPM1F Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-182-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-206 YES YES NO hsa-miR-217 YES NO YES hsa-miR-299-5p YES NO YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-425-5p YES YES YES hsa-miR-429 YES NO YES hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-613 YES YES NO hsa-miR-9-5p YES NO YES hsa-miR-96-5p YES YES YES Display: