ctcRbase

Entry Detail

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General Information

Database ID: SKCM07568 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EXOC2 Full Name: exocyst complex component 2 Category: mRNA Synonyms: SEC5|SEC5L1|Sec5p Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 485133 End Site(bp): 693111 Gene Summary: The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000112685 HGNC ID: HGNC:24968 Entrez Gene: 55770

Expression Profile of EXOC2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-543 YES YES NO Display: