| ncRNA Symbol: | IL12RB1 |
| Full Name: | interleukin 12 receptor subunit beta 1 |
| Category: | mRNA |
| Synonyms: | CD212|IL-12R-BETA1|IL12RB|IMD30 |
| Chromosome: | chr19 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 18058995 | End Site(bp): | 18098944 |
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| Gene Summary: | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
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