ctcRbase

Entry Detail

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General Information

Database ID: SKCM07695 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PTPRK Full Name: protein tyrosine phosphatase, receptor type K Category: mRNA Synonyms: R-PTP-kappa Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 127968779 End Site(bp): 128520674 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000152894 HGNC ID: HGNC:9674 Entrez Gene: 5796

Expression Profile of PTPRK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-219a-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES YES Display: