ctcRbase

Entry Detail

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General Information

Database ID: SKCM07705 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ADGRE5 Full Name: adhesion G protein-coupled receptor E5 Category: mRNA Synonyms: CD97|TM7LN1 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 14380501 End Site(bp): 14408725 Gene Summary: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] External Links: Ensembl ID: ENSG00000123146 HGNC ID: HGNC:1711 Entrez Gene: 976

Expression Profile of ADGRE5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1321 YES NO NO hsa-miR-141-3p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-21-5p YES NO YES hsa-miR-22-3p YES YES NO hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-505-3p YES YES YES hsa-miR-590-5p YES NO YES Display: