| ncRNA Symbol: | PLAUR | | Full Name: | plasminogen activator, urokinase receptor | | Category: | mRNA | | Synonyms: | CD87|U-PAR|UPAR|URKR | | Chromosome: | chr19 | | Strand: | - | | Coordinate: | | Start Site(bp): | 43646095 | End Site(bp): | 43670547 |
| | Gene Summary: | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] | | External Links: | |
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