ctcRbase

Entry Detail

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General Information

Database ID: SKCM07858 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NOTCH3 Full Name: notch 3 Category: mRNA Synonyms: CADASIL|CADASIL1|CASIL|IMF2|LMNS Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 15159038 End Site(bp): 15200981 Gene Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000074181 HGNC ID: HGNC:7883 Entrez Gene: 4854

Expression Profile of NOTCH3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-136-5p YES YES YES hsa-miR-1-3p YES NO YES hsa-miR-150-5p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-206 YES NO YES hsa-miR-296-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-369-3p YES NO NO hsa-miR-381-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-541-3p YES NO NO hsa-miR-613 YES NO YES hsa-miR-654-5p YES NO NO hsa-miR-7-5p YES YES YES hsa-miR-874-3p YES YES NO hsa-miR-875-5p YES YES NO Display: