ctcRbase

Entry Detail

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General Information

Database ID: SKCM07871 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CCM2 Full Name: CCM2 scaffold protein Category: mRNA Synonyms: C7orf22|OSM|PP10187 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 44999475 End Site(bp): 45076469 Gene Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] External Links: Ensembl ID: ENSG00000136280 HGNC ID: HGNC:21708 Entrez Gene: 83605

Expression Profile of CCM2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES NO YES hsa-miR-182-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-32-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-96-5p YES YES NO Display: