ctcRbase

Entry Detail

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General Information

Database ID: SKCM07905 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: IL7 Full Name: interleukin 7 Category: mRNA Synonyms: IL-7 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 78675743 End Site(bp): 78805523 Gene Summary: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000104432 HGNC ID: HGNC:6023 Entrez Gene: 3574

Expression Profile of IL7 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-137 YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: