ctcRbase

Entry Detail

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General Information

Database ID: SKCM07932 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PSEN1 Full Name: presenilin 1 Category: mRNA Synonyms: ACNINV3|AD3|FAD|PS-1|PS1|S182 Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 73136418 End Site(bp): 73223691 Gene Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] External Links: Ensembl ID: ENSG00000080815 HGNC ID: HGNC:9508 Entrez Gene: 5663

Expression Profile of PSEN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-133a-3p NO YES YES hsa-miR-133b NO YES YES hsa-miR-135a-5p NO YES YES hsa-miR-135b-5p NO YES YES hsa-miR-141-3p NO YES YES hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-150-5p NO YES YES hsa-miR-152-3p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-193a-3p YES NO YES hsa-miR-193b-3p YES NO YES hsa-miR-200a-3p NO YES YES hsa-miR-27a-3p NO YES YES hsa-miR-27b-3p NO YES YES hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-7-5p NO YES YES hsa-miR-9-5p YES NO YES Display: