ctcRbase

Entry Detail

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General Information

Database ID: SKCM07936 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RNF111 Full Name: ring finger protein 111 Category: mRNA Synonyms: ARK|hRNF111 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 58865175 End Site(bp): 59097419 Gene Summary: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000157450 HGNC ID: HGNC:17384 Entrez Gene: 54778

Expression Profile of RNF111 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-206 YES YES YES hsa-miR-21-5p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-452-5p YES NO YES hsa-miR-455-5p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-9-5p YES YES YES Display: