ctcRbase

Entry Detail

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General Information

Database ID: SKCM08025 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MCM8 Full Name: minichromosome maintenance 8 homologous recombination repair factor Category: mRNA Synonyms: C20orf154|POF10|dJ967N21.5 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 5950652 End Site(bp): 5998977 Gene Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000125885 HGNC ID: HGNC:16147 Entrez Gene: 84515

Expression Profile of MCM8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-147a YES NO NO hsa-miR-155-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-210-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-300 YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-429 YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-506-3p YES YES NO Display: