ctcRbase

Entry Detail

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General Information

Database ID: SKCM08047 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LCK Full Name: LCK proto-oncogene, Src family tyrosine kinase Category: mRNA Synonyms: IMD22|LSK|YT16|p56lck|pp58lck Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 32251239 End Site(bp): 32286165 Gene Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016] External Links: Ensembl ID: ENSG00000182866 HGNC ID: HGNC:6524 Entrez Gene: 3932

Expression Profile of LCK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-153-3p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-448 YES YES NO Display: