ctcRbase

Entry Detail

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General Information

Database ID: SKCM08053 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PAK1 Full Name: p21 (RAC1) activated kinase 1 Category: mRNA Synonyms: IDDMSSD|PAKalpha Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 77321707 End Site(bp): 77474635 Gene Summary: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] External Links: Ensembl ID: ENSG00000149269 HGNC ID: HGNC:8590 Entrez Gene: 5058

Expression Profile of PAK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-342-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-485-5p NO YES YES hsa-miR-758-3p YES YES NO hsa-miR-96-5p YES YES YES hsa-miR-98-5p YES YES YES Display: