ctcRbase

Entry Detail

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General Information

Database ID: SKCM08109 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ELN Full Name: elastin Category: mRNA Synonyms: ADCL1|SVAS|WBS|WS Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 74027789 End Site(bp): 74069907 Gene Summary: This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000049540 HGNC ID: HGNC:3327 Entrez Gene: 2006

Expression Profile of ELN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-144-3p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-184 YES YES NO hsa-miR-217 YES YES NO hsa-miR-299-5p YES NO YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-485-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-665 YES NO YES hsa-miR-874-3p YES YES NO Display: