ctcRbase

Entry Detail

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General Information

Database ID: SKCM08143 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SSH1 Full Name: slingshot protein phosphatase 1 Category: mRNA Synonyms: SSH1L Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 108778192 End Site(bp): 108857590 Gene Summary: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000084112 HGNC ID: HGNC:30579 Entrez Gene: 54434

Expression Profile of SSH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-101-3p NO YES YES hsa-miR-106a-5p NO YES YES hsa-miR-106b-5p NO YES YES hsa-miR-124-3p NO YES YES hsa-miR-135a-5p NO YES YES hsa-miR-135b-5p NO YES YES hsa-miR-17-5p NO YES YES hsa-miR-20a-5p NO YES YES hsa-miR-20b-5p NO YES YES hsa-miR-218-5p YES NO YES hsa-miR-27a-3p NO YES YES hsa-miR-27b-3p NO YES YES hsa-miR-31-5p YES NO YES hsa-miR-329-3p NO YES YES hsa-miR-340-5p NO YES YES hsa-miR-362-3p NO YES YES hsa-miR-519d-3p NO YES YES hsa-miR-93-5p NO YES YES hsa-miR-98-5p YES NO YES Display: