ctcRbase

Entry Detail

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General Information

Database ID: SKCM08146 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ACACA Full Name: acetyl-CoA carboxylase alpha Category: mRNA Synonyms: ACAC|ACACAD|ACC|ACC1|ACCA Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 37084988 End Site(bp): 37406818 Gene Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000278540 HGNC ID: HGNC:84 Entrez Gene: 31

Expression Profile of ACACA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-134-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-142-3p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-422a YES YES NO hsa-miR-429 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-613 YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-9-5p YES YES NO Display: