ctcRbase

Entry Detail

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General Information

Database ID: SKCM08219 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: VHL Full Name: von Hippel-Lindau tumor suppressor Category: mRNA Synonyms: HRCA1|RCA1|VHL1|pVHL Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 10141008 End Site(bp): 10152220 Gene Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000134086 HGNC ID: HGNC:12687 Entrez Gene: 7428

Expression Profile of VHL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-132-3p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-519d-3p YES YES NO hsa-miR-548o-3p YES NO NO hsa-miR-590-5p YES YES YES hsa-miR-613 YES YES NO hsa-miR-93-5p YES YES NO Display: