ctcRbase

Entry Detail

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General Information

Database ID: SKCM08226 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GAK Full Name: cyclin G associated kinase Category: mRNA Synonyms: DNAJ26|DNAJC26 Chromosome: chr4 Strand: - Coordinate: Start Site(bp): 849276 End Site(bp): 932373 Gene Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] External Links: Ensembl ID: ENSG00000178950 HGNC ID: HGNC:4113 Entrez Gene: 2580

Expression Profile of GAK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-93-5p YES YES NO Display: