ctcRbase

Entry Detail

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General Information

Database ID: SKCM08259 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GAB2 Full Name: GRB2 associated binding protein 2 Category: mRNA Synonyms: - Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 78215297 End Site(bp): 78418348 Gene Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] External Links: Ensembl ID: ENSG00000033327 HGNC ID: HGNC:14458 Entrez Gene: 9846

Expression Profile of GAB2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-124-3p YES YES NO hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-134-5p YES YES NO hsa-miR-140-3p YES NO YES hsa-miR-149-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES NO YES hsa-miR-18b-5p YES NO YES hsa-miR-24-3p YES NO YES hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-370-3p YES NO YES hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-485-5p YES YES YES hsa-miR-486-5p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-520f-3p YES NO YES hsa-miR-98-5p YES NO YES Display: