ctcRbase

Entry Detail

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General Information

Database ID: SKCM08297 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PML Full Name: promyelocytic leukemia Category: mRNA Synonyms: MYL|PP8675|RNF71|TRIM19 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 73994673 End Site(bp): 74047812 Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000140464 HGNC ID: HGNC:9113 Entrez Gene: 5371

Expression Profile of PML Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-378a-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-422a YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-541-3p YES NO NO hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES NO hsa-miR-654-5p YES NO NO Display: