ctcRbase

Entry Detail

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General Information

Database ID: SKCM08298 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PAK4 Full Name: p21 (RAC1) activated kinase 4 Category: mRNA Synonyms: - Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 39125770 End Site(bp): 39182816 Gene Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000130669 HGNC ID: HGNC:16059 Entrez Gene: 10298

Expression Profile of PAK4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-140-5p YES NO YES hsa-miR-145-5p YES NO YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-193a-3p YES NO YES hsa-miR-193b-3p YES NO YES hsa-miR-199a-3p YES NO YES hsa-miR-199a-5p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-224-5p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-340-5p YES NO YES hsa-miR-425-5p YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-485-5p YES YES YES hsa-miR-532-3p YES NO YES hsa-miR-873-5p YES NO YES hsa-miR-9-5p YES NO YES Display: