| ncRNA Symbol: | PTPN18 | | Full Name: | protein tyrosine phosphatase, non-receptor type 18 | | Category: | mRNA | | Synonyms: | BDP1|PTP-HSCF | | Chromosome: | chr2 | | Strand: | + | | Coordinate: | | Start Site(bp): | 130356007 | End Site(bp): | 130375409 |
| | Gene Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] | | External Links: | |
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