ctcRbase

Entry Detail

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General Information

Database ID: SKCM08372 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CRTC2 Full Name: CREB regulated transcription coactivator 2 Category: mRNA Synonyms: TORC-2|TORC2 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 153947669 End Site(bp): 153958625 Gene Summary: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000160741 HGNC ID: HGNC:27301 Entrez Gene: 200186

Expression Profile of CRTC2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-205-5p YES YES NO hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-423-5p YES NO YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-760 YES NO YES Display: