ctcRbase

Entry Detail

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General Information

Database ID: SKCM08431 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: APAF1 Full Name: apoptotic peptidase activating factor 1 Category: mRNA Synonyms: APAF-1|CED4 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 98645141 End Site(bp): 98735433 Gene Summary: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000120868 HGNC ID: HGNC:576 Entrez Gene: 317

Expression Profile of APAF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-21-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-429 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-874-3p YES YES NO Display: