ctcRbase

Entry Detail

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General Information

Database ID: SKCM08491 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MAPK14 Full Name: mitogen-activated protein kinase 14 Category: mRNA Synonyms: CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 36027677 End Site(bp): 36111236 Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000112062 HGNC ID: HGNC:6876 Entrez Gene: 1432

Expression Profile of MAPK14 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-185-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-24-3p YES NO YES hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-346 YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-582-5p YES NO YES Display: