ctcRbase

Entry Detail

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General Information

Database ID: SKCM08560 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TIA1 Full Name: TIA1 cytotoxic granule associated RNA binding protein Category: mRNA Synonyms: TIA-1|WDM Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 70209444 End Site(bp): 70248660 Gene Summary: The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017] External Links: Ensembl ID: ENSG00000116001 HGNC ID: HGNC:11802 Entrez Gene: 7072

Expression Profile of TIA1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p NO YES YES hsa-let-7b-5p NO YES YES hsa-let-7c-5p NO YES YES hsa-let-7d-5p NO YES YES hsa-let-7e-5p NO YES YES hsa-let-7f-5p NO YES YES hsa-let-7g-5p NO YES YES hsa-let-7i-5p NO YES YES hsa-miR-101-3p NO YES YES hsa-miR-139-5p NO YES YES hsa-miR-153-3p NO YES YES hsa-miR-155-5p NO YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-338-3p YES YES YES hsa-miR-433-3p YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-98-5p NO YES YES Display: