ctcRbase

Entry Detail

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General Information

Database ID: SKCM08584 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MBTPS1 Full Name: membrane bound transcription factor peptidase, site 1 Category: mRNA Synonyms: PCSK8|S1P|SKI-1 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 84053761 End Site(bp): 84116906 Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000140943 HGNC ID: HGNC:15456 Entrez Gene: 8720

Expression Profile of MBTPS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-93-5p YES YES YES hsa-miR-9-5p YES NO YES Display: